Rejuvenation Research: Can Infusions of “Young” Blood Increase Lifespan?
In a new study, young and old mice were surgically joined to share blood flow for three months. According to the results, the old mice did not benefit significantly in terms of lifespan.
On the other hand, young mice that were exposed to the blood of older animals had a significantly reduced lifespan compared to mice that shared blood with other young mice. The study was published July 22 in the peer-reviewed journal Rejuvenation Research. Heterochronic parabiosis is a research tool to assess the effect of organs and blood-borne factors on young and old animals. Less controlled than direct blood exchange, parabiosis is a model of blood sharing between two surgically connected animals. Iryna Pishel, of Taras Shevchenko Kyiv National University and Bienta Ltd, Kyiv, Ukraine, and her co-authors used heterochronic parabiosis between young and old mice and isochronous controls for three months. Then they disconnected the animals and studied the effects of the union on blood plasma and the lifespan of the animals.
“The most robust and interesting result of this study is the fact of a significant reduction in the lifespan of young mice from heterochronic parabiotic couples”, specify the researchers. “These data support our hypothesis that old blood contains factors capable of inducing aging in young animals. The discovery and selective suppression of the production of aging factors in the body could be the key research area for the extension of life,” they conclude. Editor-in-Chief Irina Conboy, PhD, a professor in the College of Engineering at the University of California, Berkeley, says, “This work clarifies the debated question of whether young blood or old blood controls longevity (Nature 2005, Conboy, et. Al). Are there any lasting effects of heterochronic parabiosis and if so, is it rejuvenating or aging? The work of the Pishel group has established that the lifespan of old mice does not increase after being parabiized to young mice. In contrast, young animals that have been mated to old mice suffer from a shortened lifespan, even after being mated.
Rejuvenation Research, “This finding is important for establishing the precise direction of anti-aging clinical approaches and for providing key scientific evidence against the potency of youthful blood factors in an aged organism. This work fully follows the previously published report by this group according to which infusions of young blood plasma in mice do not increase their lifespan. On a very important note, Professor Pishel conducted these fundamental studies as head of the department at Taras Shevchenko National University of Kyiv, while writing the article as a refugee, from data collected before the outbreak of the war with Russia.Such important studies were interrupted by the war, and we hope that the research will soon continue and produce more breakthroughs.
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